High Expression of the mdr, Multidrug-Resistance Gene in Advanced-Stage Chronic Lymphocytic Leukemia
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چکیده
Chronic lymphocytic leukemia (CLL) is characterized by an often indolent course with a poor therapeutic response at advanced stage. We investigated the expression of the human multidrug resistance genes mdr, and mdr, in 31 patients with CLL. Using specific probes for mdr, and mdr, mRNA, respectively, expression of both genes could be found in 29 of 31 patients. Of those, nine had high expression of mdr, and 13 of mdr,. Although 29 of 31 patients showed coexpression of mdr, and mdr3, the mRNA levels were not interrelated. Prior treatment did not significantly influence
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تاریخ انتشار 2003